The rise of nicotinamide mononucleotide (NMN) supplements are constantly increasing in their popularity. This particular ingredient has already been linked to repairing DNA, supporting energy production, and even reducing the appearance of aging. According to many studies, using NMN supplements can be highly beneficial to the user’s health.
All reliable versions of this supplement have been proven to support anti-aging effects, but they aren’t all equal. After thoroughly testing the different options on the market, this guide goes through many of the options offered to consumers today to determine the best ones.
Ranking the Top NMN Supplements
Every NMN supplement is different, which makes it difficult to narrow them down for the right choice. While some versions have tons of NMN with other ingredients, others focus on proprietary blends that make the remedy effective.
After thorough testing, the final rundown of the best NMN supplements includes:
- Liposomal NMN+
- Wonderfeel NMN
- Tru Niagen
- Life Extension NAD+ Cell Regenerator
- Cymbiotika NMN
- Alive By Nature Sublingual NMN
- Liftmode NMN
Read on below to learn more information about the way that each of these supplements help with NMN’s benefits.
Liposomal NMN+, a remedy from Genuine Purity, is one of the top NMN supplements that the market has right now. Users need two capsules of this supplement each day to help with cellular regeneration and the general function of mitochondria. With proven ingredients, this formula also helps with DNA health.
According to the creators, this formula only takes about two weeks to be effective. Consumers should notice the difference in the way that they age. Consumers take this product to look and feel younger, allowing users to exclusively get NMN. With a vegetable cellulose capsule, this active ingredient won’t break down before the body is able to properly absorb it.
The 250mg dose of NMN matches what clinical trials use to check effectiveness. A few other ingredients help consumers to absorb it more effectively, providing incredible value with $69.95.
Wonderfeel NMN is a helpful way to improve the human body. It uses a patented version of NMN, increasing NAD levels and changing the adjustments that consumers go through with age. Users get 900mg of NMN in every serving, which is two capsules. It stands as one of the strongest doses in this guide, and it even exceeds the amount that clinical trials use.
Developed by Dr. Andrew Salzman, this remedy has the support of a Harvard-trained medical doctor and biomedical scientists. He personally is the holder of 50+ patients during these 30 years of research. It helps consumers to improve their focus and clarity while improving athletic performance and youthful energy. The total cost of this formula is $88.
Tru Niagen helps consumers to naturally increase NAD levels with 300mg of NMN per capsule. Users won’t need more than a capsule every day to get the desired effects. Consumers can purchase it in stick packs as well to work with their preference.
When NAD levels improve, consumers might see a boost of up to 51%. It helps consumers with anti-aging benefits, and it is backed by the support of two Nobel Prize winners. However, the reason that Tru Niagen stands out against other products is because it offers nicotinamide riboside (NR), which is also a precursor to NMN. It helps consumers to improve their aging, brain health, heart health, and more. It is available for $47.
Life Extension NAD+ Cell Regenerator
Life Extension NAD+ Cell Regenerator helps consumers to improve their cellular aging with NR. It works with the same amount of NMN as Tru Niagen does, offering a substantial boost in NAD production. For just over $40, consumers get a 30-day supply of this supplement, only requiring a capsule per day. Most users report that they feel less fatigue and more energy.
This formula uses science-backed ingredients to support these effects as well. Some of those ingredients include ashwagandha, multivitamins, brain health supplements, digestive health aids, and more. For one bottle, the total cost is $69.
Cymbiotika NMN is a premium formula that combines NMN with trans-resveratrol. It reduces oxidative stress while supporting healthy DNA. It also reduces premature aging, supports energy levels, and more. It works as a precursor to NAD, and it has several complementary ingredients like apigenin, green tea extract, and resveratrol.
With all of these ingredients, the ingredients all boost anti-aging benefits, giving users an additional boost for their cognition. It also comes from a company that is known for their premium supplements, and it costs $77.
Alive By Nature Sublingual NMN
Alive By Nature Sublingual NMN is available as a powder that goes under the tongue, taking just 30 seconds to fully absorb. It was one of the two NMN supplements that this list has that doesn’t use a capsule, allowing absorption to be more effective. It offers 125mg of NMN with every serving, though some people find that consumers take a higher dose to get maximum absorption.
While the powder makes it more effective, it doesn’t get a spot closer to the top of the list because of the FDA. In 2020, a warning letter was issued by the FDA to this company in Florida because of claims that it could be used as a potential remedy for the COVID-19 virus. While Alive By Nature proceeds with the changes needed, these formulas are still rather difficult to come by, despite a $59 price tag.
Liftmode NMN is available as a powder as well, just like Sublingual NMN by Alive By Nature. It costs $26.68 for 5 grams, and it offers an incredibly strong dose of NMN. It offers incredible anti-aging benefits, helping users to get the best results by using micro-batch production and vacuum sealing of the remedy. All of these products come with the support of an independent third party.
Consumers can choose from two other sizes for these formulas, depending on what the user wants to have on hand.
Elysium has a whole lineup of high-quality ingredients that allows consumers to find exactly what they need. The company has already established partnerships with Oxford and Yale, giving them incredible access to new research. The work that the company has already done earned them NSF Certified for Sport certification, showing their purity and quality. This close relationship also allows the brand to invest in clinical trials, putting their own products through 13 separate studies.
With many different anti-aging formulas, consumers can order the following products from Elysium:
Consumers get 250mg of NR in every two capsules of the NMN supplements. It helps users to improve their NAD. It also uses pterostilbene to improve the effects. The total cost is $69.
Deciding the Rankings of the Top NMN Supplements
To add these products to the list of the top NMN supplements for the year, certain criteria had to be met. Here’s a look at the different questions that the guide asked while compiling the list.
- Does the supplement have at least 98% pure NMN?
- Does the formula have high-quality NMN?
- Is there enough NMN in the supplement to be effective?
- Does the formula include any ingredients to complement the benefits?
- Does this formula include advertising for anti-aging benefits?
- Are there any ingredients to preserve NMN during digestion?
- Does the formula contain at least 250mg of NMN to get the desired benefits?
- Does the company show where they manufactured the products?
- Is the company transparent about the ingredients, type of facility, and other parts of the processing facility?
- Does the company have a certificate of analysis to prove the concentration that they claim?
- Does the supplement come with a money-back guarantee?
- How long is the money-back guarantee?
- Are there any other warranties that apply?
- Does the supplement come at a fair price?
- Does the price match the value that consumers get from the product?
With all of these factors considered, this guide included other considerations that could help consumers to make a choice. The manufacturer played a big role in the supplement’s ability to improve the user’s results, which is why trusted companies were the priority. These companies had to be consistent, high-quality, and show a consistent track record of positive performance.
Finding products that have the support or advice of doctors on staff was also a major advantage. Some of the products here were even made by actual doctors, which gives added validity that isn’t found anywhere else. Some of the other brands showed the contributions that they’d received from medical researchers and other medical professionals.
How Does NMN Work?
NMN is used to help consumers to improve their body’s natural production of NAD+. Current research on NAD+ shows that consumers can get anti-aging benefits from this ingredient, which is why many people supplement it.
Unfortunately, these same studies show that consumers can’t just take NAD+ to get the benefits, but that’s where NMN comes in. Most of the NAD in the body comes from vitamin B3, helping users to naturally boost NAD. Using NMN is backed by substantial scientific research.
When consumers get NAD+ at the right level, they can potentially increase their lifespan and experience incredible cognitive and physical effects. It has been carefully studied by researchers for its effects, but most people don’t keep producing enough NAD with age. By supplementing after age 40, it can drastically improve NAD production.
NAD+ is usually highly abundant when it is produced at the right level, but NAD tends to be unstable. Using a precursor is the best way to improve it, which is where NMN comes in.
Benefits of NMN
There are many different reasons that consumers might choose to use NMN. Some people enjoy the support it offers when they want to look and feel younger. Others want to improve their metabolism, promote weight loss, or improve their health.
According to the current research on NMN, using this ingredient can help with:
- Increasing daily energy.
- Promoting better heart health.
- Supporting good sleep.
- Improving DNA repair.
- Increasing weight loss with a better metabolism.
- Supporting mitochondrial energy.
- Improving youthful appearance and energy.
- Increasing lifespan.
- Improving joints.
- Enhancing muscle strength.
- Reducing high blood pressure.
- Promoting better memory recall.
- Increasing sex drive.
- Reducing joint pain.
- Improving mobility.
Many benefits continue to be unveiled with current clinical research.
Why Doesn’t NMN Work for Everyone?
When it comes to any new supplement, consistently using it is the key to success, but there are many people that NMN simply doesn’t suit. Unfortunately, consumers sometimes are disappointed to find that this remedy isn’t the right solution for their needs. Some people claim that it isn’t truly effective at all, while others focus on blaming the supplement brand responsible for it.
The main reason that consumers don’t experience the changes that NMN aims to bring is if they aren’t a legitimate product. Far too many products offer a blend of B vitamins and herbs to make it seem as though the remedy is working. In reality, there’s not a lot of NMN working at all.
If the supplement is legitimate, the problem might be that it isn’t absorbing properly. NMN is hard to absorb because the digestive system breaks it down substantially. To avoid this issue, some companies include fatty molecules to make them more sustainable.
If the product is authentic, and consumers absorb everything that they should, the company might have the dosage wrong. They might even have purity wrong, which means that consumers aren’t getting everything that they could from these types of supplements. Using one of the top-ranked supplements on this list is the key to that success.
Scientific Evidence for NMN Supplements
According to the current research on NMN supplements, using this remedy is meant to help consumers improve the appearance and effects of aging. This research proves that supplementation with NMN helps with heart health, brain health, and other areas of good health. Let’s discuss some of the ways that NMN is scientifically proven to help.
More Cellular Energy
The main reason that a lot of people initially start using NMN supplements is because they want more energy. This ingredient helps consumers to improve their physical and cognitive energy because it boosts cellular energy, supporting the mitochondria with a powerful effect. According to a study in 2016, researchers determined that age directly influences mitochondrial dysfunction. The body simply isn’t able to function without the same NMN as when they were younger.
Better Physical Performance
When the mitochondria gets a boost in energy from these supplements, many people report improved endurance and better physical performance. In a study in 2017, researchers found that using NMN helps to trigger the production of NAD, helping them to reduce physical damage and promote physical performance.
Improved Cardiovascular Health
There is no greater killer than heart disease, which is part of the reason that so many people appreciate what NMN can do. A study in 2016 showed that supplementing with NMN helps users to improve their cardiovascular function with better blood flow. It reduces inflammation, and it helps users to improve their overall health.
When consumers use NMN, they improve immune function, making it easier to fight against disease and sickness. In a study in 2024, researchers discovered that using NMN helps with the reprogramming of macrophages, which makes it possible for the immune system to work more effectively. Like other studies, consumers will find that the reduced inflammation is a significant benefit.
Better Brain Health
Using NMN helps consumers to feel and look younger than they’ve ever been. It promotes better brain health with the improved cellular activity. A study in 2014 confirmed that consumers improved the survival rate of cells, especially in the brain. It improved how well brain cells endure to reduce the risk of degenerative brain conditions.
Another study in 2019 showed researchers that it could help with brain health in other ways as well, helping them to perform just as well as younger mice during cognitive tests.
Faster Metabolism With More Weight Loss
Metabolism doesn’t function at the same rate as the body gets older. With the revival of cellular energy, NMN is considered to be helpful to consumers who want to promote weight loss. When metabolism is faster, consumers improve how effectively they burn through calories. In a 2016 study, researchers found that older mice increased their metabolism, matching the rate that younger mice experience.
DNA Repair Support
DNA repair is another big reason for using NMN. While this benefit may seem a little vague, supporting DNA repair means that consumers improve their overall health and wellness. When the body doesn’t have enough NAD, repairing DNA on its own is difficult. Using an NMN supplement is the easiest way to support DNA repair.
Better Vision and Eyesight
In some studies, using an NMN supplement has been associated with better vision. When consumers have their support, they can reduce the risk of photoreceptor degeneration, which means that consumers can improve their vision quickly. It is sometimes helpful for individuals who deal with dry eye syndrome.
When consumers experience a lot of inflammation, they increase their risk of disease and illness. As the root cause of many health issues, NMN is used daily as a way to protect users against inflammation. It also reduces free radicals that could otherwise trigger inflammation.
Balanced Blood Sugar and Insulin Production
In a 2020 study, researchers stated that using NMN supplements helped with insulin secretion. It also helps the body to properly process insulin, making it more effective when bringing down blood sugar levels.
Improved Musculoskeletal Structure
Someone who doesn’t have adequate levels of NAD also struggles to maintain their musculoskeletal structure. When adults get older and improve NAD levels like they used to have, they can improve NAD levels with exercise and diet.
Legal Issues of Purchasing NMN Supplements
While NMN supplements are fairly popular, they’ve been around for over a decade already. Using it daily for anti-aging benefits is one of the most common reasons that consumers have it. Unfortunately, the incredible effects might be too much for some people.
In November 2024, the Food and Drug Administration decided to ban beta-nicotinamide mononucleotide (B-NMN) from being available in supplements. This ingredient presently is being researched to use as a new medication, so it is ineligible as a dietary supplement. Despite being sold safely for years, consumers will have to adjust what they need to do to procure these supplements legally.
Before the FDA imposed this law, NMN was classified as a new dietary ingredient, which is why supplements sold it so willingly. This ruling was revoked in October 2024, which means that consumers could not get it in the United States. Companies are consistently pushing past this ruling, pushing for the government to understand the safety of NMN supplements.
FAQs About NMN Supplements
What is NAD?
NAD stands for Nicotinamide adenine dinucleotide, but it also goes by NAD+. Produced in the body in all cells, it is important to repair DNA and restore energy levels. It reduces inflammation, supports cellular signaling, and improves other areas of health.
Why do people usually take NAD supplements?
Most people like NAD and NMN supplements because they want to reap the anti-aging benefits, allowing users to remain cognitively sharp and physically ready for whatever’s next. They work at all ages, especially for anyone who wants to reduce inflammation and improve their heart health.
What makes NAD so important?
The aging process forces NAD levels to drop drastically, making it harder for consumers to stay focused and be physically active.
What are NMN supplements?
These supplements help the body to naturally produce more NAD. It offers a dose of nicotinamide mononucleotide, working quickly to increase how fast the body creates it again.
Are these supplements safe?
According to current research, most people can safely use NMN supplements. There are no adverse effects associated with it, even if the user takes more of it than they are supposed to. If there are any concerns, consumers should consider speaking to their doctor first to ensure that this remedy is safe for use with medication or some medical conditions.
How are NMN and NAD supplements different?
NAD is produced by the human body already, though it could be used in its natural state for supplementation. Unfortunately, it isn’t stable, and its lack of popularity means that consumers might not find it easily. Instead, many companies use NMN to naturally increase NAD levels of the body.
Can consumers order NMN supplements online?
Since November 2022, the Food and Drug Administration decided that the research on NMN as a pharmaceutical drug means that it cannot be sold as a supplement. NMN supplements come with restrictions when sold online by some retailers, while others make it easy. The legal issues surrounding NMN supplements are constantly changing, so consumers will need to check their local laws when they place their order.
How can consumers get NAD in the foods that they consume?
Chicken, tuna, turkey, and edamame all help consumers to increase the amount of NAD in their body.
What does an NMN supplement do?
When consumers take NMN, consumers feel more youthful and healthier. It helps them improve cognition and physical activity. Some people use it for specific goals if other ingredients are involved?
What is the right doses of NMN?
In clinical studies on the effects of NMN, many consumers find that using 250mg is enough to give them the right support. Some people take up to 1000mg in these studies, which is completely safe.
Who is Dr. David Sinclair?
Dr. Sinclair is a professor at Harvard University, leading the way in NMN and NAD research. It also is part of several research groups who seek to understand the anti-aging effects that NAD and NMN bring.
How can consumers consistently boost NAD levels?
Using an NMN or NR supplement is one of the easiest ways to improve NAD production. Maintaining a healthy diet and exercise routine is a helpful way to improve NAD levels. It is possible that the right lifestyle habits are enough to maintain NAD levels for older and younger adults alike.
Will high intensity interval training improve NAD levels?
Participating in rapid burst of exercise with incredible intensity – like HIIT – can naturally improve NAD levels.
What is the top NMN supplement on the market today?
Based on the data compiled in this guide, the top NMN supplement comes from Genuine Purity – Liposomal NMN+. Other helpful options include Wonderfeel NMN, Tru Niagen, Elysium NMN, and Life Extension NAD+ Cell Regenerator.
Why are the NMN supplements expensive?
The majority of the supplements with NMN today require a lot of money to manufacture, and companies have to adjust accordingly. For NMN with high purity, more work is needed to make them available, and the high popularity of this type of product ensures that consumers consistently want to buy it.
How do consumers take NMN?
These supplements are available within capsules. Most remedies only require a capsule a day to get the desired effects. Some companies offer it as a powder instead.
When is the best time of day to take NMN?
Most people start the day with NMN capsules to make sure that they get the best absorption possible.
The growing popularity of NMN supplements have made them increasingly popular. It improves NAD levels, and it helps users to protect themselves from the changes that come with improved physical and cognitive aging. Consumers who want to change the way that their brain and body react. The formulas are easy to use, and anyone can include them in their routine.